Proline-Modified DNA as Catalyst of the Aldol Reaction
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چکیده
منابع مشابه
Proline-modified DNA as catalyst of the aldol reaction.
DNA templated synthesis has emerged as a powerful tool to steer reactivity by modulating nature s approach to increase the effective molarity of the reactants. By making recourse to the inherently selective duplex formation properties of cognate DNA strands, small molecule reactants are brought to close proximity increasing the effective molarity and thereby significantly accelerating chemical ...
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Protonated N'-benzyl-N'-l-prolyl-l-proline hydrazide has been developed as a highly enantioselective catalyst for the asymmetric direct aldol reaction of aromatic aldehydes with ketones.
متن کاملNew mechanistic studies on the proline-catalyzed aldol reaction.
The mechanism of the proline-catalyzed aldol reaction has stimulated considerable debate, and despite limited experimental data, at least five different mechanisms have been proposed. Complementary to recent theoretical studies we have initiated an experimental program with the goal of clarifying some of the basic mechanistic questions concerning the proline-catalyzed aldol reaction. Here we su...
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In this paper the equilibrium properties of the proline catalyzed aldol reaction was studied. The use of wellestablished methodologies, like reaction progress kinetic analysis and linear free energy relationship analysis, led to the quantification of the reaction reversibility and to its correlation with the substrate electronic activation. Due to these experimental observations, common computa...
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Zn complexes of proline, lysine and arginine are efficient catalysts for the aldol addition of p-nitrobenzaldehyde and acetone in aqueous medium, giving quantitative yields and enantiomeric excesses up to 56% with 5 mol% of the catalysts at room temperature.
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2007
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.200701416